Research Projects

Current research projects at the PTRC

Jason L. Sperry

  • Pragmatic, Prehospital Group O Whole Blood Early Resuscitation Pilot Trial(PPOWER). (07/2017–05/2020)
  • Linking Investigations in Trauma and Emergency Services (LITES) Network. (09/30/2016-09/29/2025)
  • Role of erythroid DAMP molecules in the pathogenesis of vascular injury in sepsis. (02/1/2015-01/31/2020) 
  • Analysis and Characterization of Trauma Induced Coagulopathy. (09/01/2013- 08/30/19)

Matthew D. Neal

  • Utilization of Thromboelastography to Monitor Rivaroxaban Activity in Trauma and Emergency Surgery. (03/01/2016-02/28/2019)
  • Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After Trauma. (09/01/2016-05/31/2021)
  • SynthoPlate Nanotechnology For Intravenous Hemostasis and Wound Healing in Prolonged Field Care. (09/30/2017-09/29/2020) 
  • Strategies to Promote ResiliencY (SPRY-1) - A UPMC REMAP Initiative. (2/1/18 7/31/19)
  • Testing for Platelet Inhibition before and after platelet transfusion in Traumatic Brain Injury (TPI-TBI). (01/01/2018-12/31/2020) 
  • Pragmatic, Prehospital Group O Whole Blood early Resuscitation Pilot Trial. (07/01/2017-05/31/2020)
  • Linking Investigations in Trauma and Emergency Services (LITES). W81XWH-16-D-0024
  • Analysis and Characterization of Trauma-Induced Coagulopathy. (06/01/2018-05/31/2019)
  • Engineering Biologic Topography into Vascular Grafts. (09/15/2018-08/31/2019)

Timothy R. Billiar

  • Training in Trauma and Sepsis Research. (07/01/2009-06/30/2019)
  • Mechanisms of Immune Dysfunction after Trauma and Surgical Sepsis. (05/01/2018-04/30/2023)
  • A Novel Regulation of the Phase II Enzyme Estrogen Sulfotranferase. (08/01/2014-04/30/2019)
  • Immunometabolism in Sepsis. (07/15/2015-05/31/2019).
  • Mechanisms of Immune Dysfunction after Trauma and Surgical Sepsis. (09/30/2017-09/29/2021)
  • A Precision Medicine Approach based on Discrete Time Windows for Predicting Outcomes of Polytrauma Patients. (01/01/2018-12/31/2020)

Brian Zuckerbraun

  • Role of erythroid DAMP molecules in the pathogenesis of vascular injury in sepsis. (04/01/2015-03/31/2020)
  • Mitochondria as Immune Regulators in Sepsis. (11/01/2017-10/30/2021).
  • Analysis and Characterization of Trauma Induced Coagulopathy. (09/01/2013-08/30/19).
  • CAMK: Central regulators of the response to surgical sepsis. (05/01/2017-04/30/2019).
  • Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction after Trauma. (11/01/2016-10/30/2021).
  • Study of Tranexamic Acid During Air Medical Prehospital Transport Trial (STAAMP Trial). (02/01/2015-01/30/2019).

Yoram Vodovotz

  • Modeling of Cytokine Networks and Gene Expression Profiles Mediating Rejection in Vascularized Composite Allotransplantation. (07/01/15 – 06/30/19)
  • Palliative care intervention for socioeconomically disadvantaged cancer patients. (06/01/15 -05/31/19)
  • The Major Extremity Trauma and Rehabilitation Research Consortium. (07/01/16 –06/30/21)
  • Detailed Analysis of the Inflammatory Milieu of Patients Receiving a Left Ventricular Assist Device. (04/01/17 – 10/31/18)
  • Technology Assisted Stepped collaborative Care Intervention (TASCCI) to Improve Patient-centered Outcomes in Hemodialysis Patients. (07/05/17 – 06/30/22)
  • Modeling Brainstem Inflammation's Role in Systemic Dysfunction during Sepsis. ( 04/01/17 – 03/31/22)
  • Surgery triggered immune response and liver metastases (04/01/17 – 03/31/22)
  • A Precision Medicine Approach Based on Discrete Time Windows for Predicting Outcomes of Polytrauma Patients. (01/01/18 – 12/31/21)
  • Immune Fingerprinting Signatures in Predicting Successful Aging. (01/01/19 – 12/31/22)

Melanie J. Scott

  • Inflammasome activation in trauma/ hemorrhagic shock. (07/01/12-12/30/22)
  • Mechanisms of platelet exosome-mediated acute chest syndrome in sickle cell disease (06/01/19-03/31/24)

Matthew R. Rosengart

  • Phenytypic Renal Cases in Sepsis and surgery for Early Acute Kidney Injury (PReCISE AKI). NIH/NIDDK (07/01/2017 – 06/30/2022)
  • Blue light protects against ischemia-induced organ injury. (09/20/2016 – 06/30/2020)
  • CAMK: Central Regulators of the response to surgical sepsis. (08/03/2015 – 07/31/2019)
  • Developing a novel intervention to make physician heuristics a source of power (10/01/2015 – 09/30/2020)

Bryan W. Tillman

  • A Rapid, Temporary Distal Perfusion Stent for Hemorrhagic Injuries of the Torso (2016-2020)
  • An Organ Perfusion Stent as an Alternative to Surgery in Donor Organ Recovery (2017-2021)
  • E-mag System for Rapid Cannulation of Fenestrated Stent Grafts to Reduce Radiation Exposure (2018-2019)

​Jie Fan

  • Cell Priming, Receptor Cross-talk, and Acute Lung Injury/
  • Macrophage Pyroptosis Mechanism of Post-Trauma Acute Lung Injury
  • Improvement of Organ Function after Severe Hypovolemia
  • Cell Death Mechanism of Acute Lung Injury in Sepsis
  • PXR-mediated xenobiotic response in the pathogenesis hemorrhagic shock
  • A Novel regulation of the phase ii enzyme estrogen sulfotransferas