Timothy R. Billiar, MD
- George Vance Foster Professor and Chair, Department of Surgery
- Distinguished Professor of Surgery
- Executive Vice President and Chief Scientific Officer UPMC
- Associate Senior Vice Chancellor For Clinical Academics, University of Pittsburgh
My laboratory and research program have long-standing interest in the host response to severe trauma and sepsis. We have worked extensively with human systems as well as small animal models of multisystem injury and sepsis sought to understand the mechanisms leading to immune system activation, immune dysfunction and organ dysfunction. We have contributed to the understanding of the role of nitric oxide, pattern recognition receptors and damaged associated molecular patterns as regulators of the immuno-inflammatory response to injury and sepsis. Most recently we have advanced the understanding of the human injury response through the application of single cell omics and multi-platform, multi-omics in severely injured patients. This included the first large scale multi-omic analysis of the human response to severe injury.
Representative Publications
Dr. Billiar's publications can be reviewed through PubMed.
Research Interests
Dr. Billiar’s laboratory is currently funded by the NIH to investigate both research areas, including a Trauma Center Grant and a T32 training grant. He also holds seven U.S. patents associated with his research. The goal of all his research is to define mechanisms and identify therapeutic targets.
Research Grants
Dr. Billiar’s laboratory is currently funded by the NIH to investigate both research areas, including a Trauma Center Grant and a T32 training grant. He also holds seven U.S. patents associated with his research. The goal of all his research is to define mechanisms and identify therapeutic targets.
- Program Director: Training in Trauma and Sepsis Research, NIH grant #T32-GM-08516, 7/01/14-6/30/2019
- Co-investigator: Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1, NIH grant #R01-GM098474, 4/1/12-3/31/17
- Co-investigator: The role of caspase-1 in trauma and hemorrhagic shock, NIH grant #R01-GM102146, 12/1/12-11/30/17
- Principal Investigator: Nitric Oxide and Hepatic Function in Sepsis and Trauma, NIH grant #2RO1-GM044100-24A1, 5/1/14-3/31/18
- Co-investigator, Endogenous regulators of inflammation in liver ischemia/reperfusion, NIH grant #R01GM095566, 9/15/11 – 5/30/16
- Co-investigator, WISP1 and TLR4 Signaling in ventilator-induced lung injury, NIH grant #R01GM108639, 7/1/14- 6/30/19
- Co-investigator, A Novel Regulation of the Phase II Enzyme Estrogen Sulfotranferase, NIH grant #R01ES023438, 8/1/14-4/30/19